Drive around the lakes, not through them. No problem.
What is that distance? 500ish miles or so give or take 100 miles? A typical CB motorcycle can go 150 miles between refuelings and that's just several refuelings done in a straight line instead of a circle back to home. No problem for the motorcycle. The rider/drive is the biggest problem on long range operations for any vehicle.
If it's your first time moderate range, don't do the entire thing in one day. (500 miles in a day isn't fun even with a lot of long range experience) Plan on 250-300 miles per day with a mandatory 24 hour break after any 3 consecutive days. Less miles per day if you're out of shape, not wearing proper gear, not proficient.