The drive chain came off?

That won't happen with a properly adjusted and properly maintained drive hardware.
Have you adjusted the chain? Is it too loose? Has it been too tight?
What does the driven sprocket, rear sprocket and chain look like?
Where precisely is the sound coming from?
+1 on all of what he said.
A chain coming off at speed can cause some serious damage, not to mention a crash.
Did the sound start immediately after the chain coming off? If you don't have a center stand, you need to get the rear of the bike off the ground (while stationary) so you can rotate the rear tire and locate the source of this sound. Could be something simple, could be something major.